Both clubs have appealed for the 80,000-plus fans inside the stadium and those outside to behave responsibly and ensure that football is the winner on an eagerly-anticipated day in North-Rhine Westphalia.
"It is a special game in a special atmosphere between two sides with special quality," said Dortmund coach Jurgen Klopp, whose side currently find themselves two points behind the Royal Blues.
"We have the advantage of playing at home - and that is the only advantage we have got, but it will have to suffice."
The Yellow wall, as one of the largest stands in Europe behind one of the goals is known, will do all it can to keep Schalke away and draw the home team in.
Schalke coach Huub Stevens is aware of the unique atmosphere with this being his 15th Revier derby, but he says it does not cause him any concern and must not intimidate his players either.
"We know it is not going to be easy," he said. "But we will not hide.
"It would be ill-advised to have any fear. We are looking forward to the game."
Dortmund have several injury worries, with Mario Gotze ruled out and both Marcel Schmelzer and Ilkay Gundogan carrying knocks.
Jakub Blaszczykowski is also unavailable, meaning Chris Lowe may be thrust into his first game since April.
Stevens can pick from almost a fully fit squad now that goalkeeper Timo Hildebrand is available again, but the Dutch coach has not yet decided which of his three goalkeepers will be the chosen one.
"We have three very good goalkeepers and all of them have been performing well in training," he said.