Prior to February's 2-2 draw between the two clubs at the Dreisamstadion, Werder had won seven successive matches against Freiburg, including several emphatic victories such as 5-3, 4-0, 6-0, 4-1 and 6-0.
In total, Freiburg have conceded 37 goals in their last 10 meetings with Bremen and Streich knows his players will need to be on their toes or risk another mauling.
"We have got to give everything against Bremen," he said at a press conference. "Anything less than everything would mean we get beaten, heavily."
However, Streich insists his side are not fretting about their poor results against Bremen heading into the clash.
"We have no fear because of that - we are looking forward to it," he said .
Bremen coach Thomas Schaaf is not paying much heed to the past meetings between the two either, saying: "The record in recent games is not even in the back of our minds. We need to find solutions for this game.
"I never think about statistics because you can twist and turn them until they suit you."
Bremen, who have picked up four points from their opening four Bundesliga games - one point less than their opponents - flew down to Freiburg without the suspended Assani Lukimya, but with Felix Kroos.
"Felix has shown some promising performances in training and with the youth team and that is why he has earned a place in our team," Schaaf said.
"He is very versatile and can play both in the defence and the midfield.
"We always had very high hopes of him, but the speed with which he has developed has surprised us."
Streich has no injury worries and can count on a fully-fit squad on Wednesday night.