Their opponents at the HSV-Arena are Borussia Dortmund, who have not lost in 31 games and also picked up a morale-boosting 1-0 win over Ajax in the Champions League in midweek.
It may be a tall order for a side who have lost their first three league games of the season, as well as being eliminated from the DFB-Pokal in the first round, but it is one they are ready to face.
"We have nothing to lose," said their coach Thorsten Fink. "Above all, we want to enjoy ourselves."
According to the former Basel coach, who is under pressure after the club started the season with three defeats for the second year running, facing the defending champions "could not come any better" for his side.
"We will be the rank outsiders," he said. "We did well against Bayern last season in this kind of situation so why should that not happen this time against Dortmund?"
The pressure will nevertheless be high with the weight of expectancy even greater now that Rafael van der Vaart has returned from Tottenham.
He will make his second home debut on Saturday and insists everything is not as gloomy as it appears in northern Germany.
"I am very optimistic," he told the Hamburger Abendblatt newspaper. "Our team have a lot of talent and I mean that seriously.
"This talent just needs time to develop."
Dortmund's development has been unrivalled over the last two years, but part of the spine of the team could be missing on Saturday.
Goalkeeper Roman Weidenfeller and midfielder Ilkay Gundogan both have flu and could miss out while coach Jurgen Klopp is pondering other changes to his side in view of Tuesday's trip to Frankfurt and a clash with Borussia Monchengladbach next Saturday.
Dortmund then travel to Manchester City as part of a busy schedule of matches before the next international break.
"We are going to have to look all of the lads in the eyes and then decide who is allowed to play," said Klopp.