The defending German champions have slipped five points behind league leaders Bayern Munich on the back of their first home defeat in over a year last weekend, while they only managed a 1-1 draw on their Champions League group stage debut.
Having guided the club into the Europa League in his first year in charge and then to the title last season, Klopp is a stranger to such difficult moments, but he is keen to rise to the adversity.
"The motivation is huge to master this situation," he said at the pre-match press conference.
"The plan is not to moan about not being able to call upon our best line-up, but rather to see this as a chance to do something special against Hannover.
"I will send a team out who is capable of putting our plan into action."
Klopp is without the suspended Mario Gotze and Sebastian Kehl while Sven Bender is injured.
"I would have preferred not to have had this problem," admitted Klopp, who is likely to give Ilkay Gundogan a start with Antonio da Silva another option for the midfield.
Ivan Perisic, whose wonder goal against Arsenal earned Dortmund a Champions League point in midweek, could also be given a rare start in place of Gotze.
Hannover also picked up a point in Europe this week, starting their Europa League group stage with a 0-0 draw against Standard Liege.
But now it is back to the Bundesliga, where the Reds have one point more than Dortmund, and their coach Mirko Slomka intends to extend that gap.
"We want to win, like we want to win every game," he said. "We have lost only one of our last 10 Bundesliga games so why should we be afraid just because the defending champions are coming?"
Slomka is also without several key players, with Mohammed Abdellaoue and Christian Schulz both sidelined.