Four games and four wins in the Bundesliga give Mainz a clear advantage in the head-to-head stakes and Tuchel feels this is something that his side can use in their favour.
"I think it is only luck, but if there is a small psychological advantage, then we will try to use it," he said at the pre-match press conference.
"If we believe that Hoffenheim cannot win in Mainz, then that is the first step towards ensuring it doesn't happen this time."
None of those victories came against current incumbent Holger Stanislawski, although his own personal record against Mainz is equally poor.
He lost 4-2 at home and 2-1 in Mainz as coach of St Pauli last season, but says such streaks must always come to an end.
"We have a new coach and so it's time for a new streak," he proclaimed.
"It will be a difficult task, but we want to take the points from Mainz that we let slip in our home game against Werder Bremen."
Sejad Salihovic will miss out after picking up an injury during Bosnia's 1-0 win over Belarus on Tuesday.
"We hope that he can start light training again at the start of next week and maybe play a part against Wolfsburg," said Stanislawski.
Daniel Williams could replace him and, therefore, make his Hoffenheim debut following his transfer from Freiburg this summer.
Mainz are without Adam Szalai and Florian Heller, but Mario Gavranovic could make his debut after joining on loan from Schalke until the end of the season.