Leverkusen face Chelsea, Valencia and Genk, while Dortmund also have English opposition in the form of Arsenal, alongside Marseille and Olympiakos.
And ahead of Saturday's clash between two of Germany's three Champions League participants, both coaches took time out to summarise their tasks away from the Bundesliga between now and Christmas, with both sides are aiming for a place in the last 16.
"We have been drawn against three great teams and I am really looking forward to the Champions League," said Dortmund coach Jurgen Klopp.
"It is not going to be easy. It may easy logistically, but not to play," said his Leverkusen counterpart Robin Dutt.
"Chelsea and Valencia certainly aren't unknown and we got to know Genk in pre-season as a strong opponent."
However, Dutt does not want this European experience to be a one-off and he is aiming for a win over Dortmund on Saturday to help them on the road to Europe again next season.
"The Bundesliga is our daily bread," he said.
"We are looking forward to the Champions League and the famous opponents, and we have the aim of reaching the next round, but we still need to perform each weekend.
"The big challenge is to keep performing on Saturday and be able to switch from Wednesday to the weekend without losing quality."
At least Leverkusen have a big enough squad to cope with the dual responsibility, and Dutt again has to choose between Simon Rolfes and Michael Ballack for a place in the midfield, as well as the captain's armband, on Saturday.
Germany international Mario Gotze could miss out for Dortmund due to a groin strain, while Sven Bender is back and should be able to line up against his brother Lars.