Both are their respective team's top goalscorers with Ba having netted six of Hoffenheim's 22 goals this season and Cisse accounting for nine of his side's 17 strikes, and both will be looking to lead their side into the top four.
And Hoffenheim coach Ralf Rangnick knows his side will have a better chance of winning if they can prevent Cisse from scoring.
"He is in a really good condition and has very few weaknesses," said the Hoffenheim coach.
"Therefore, we have got to get to grips with him. Cisse is in excellent form, but we have good defenders who can challenge him."
But Rangnick has also warned his side not to focus on only one man.
"Freiburg are such a balanced side," he said.
"They have no star in their team who I would like to pick out and that is what makes them so strong."
Freiburg coach Robin Dutt said he would not trade his Senegalese striker, who has scored in each of his last five games.
"I am happy with my own Demba, but I do think that Demba Ba has improved extraordinarily well recently," he said.
He too praised his opponents' "balanced" side and said they "are individually stronger than Mainz", the side his team beat 1-0 last weekend.
Around 3,000 Freiburg fans will make the shortest away trip of the season for them.