On October 28, 2012, Stefan Kiessling and Sidney Sam earned Leverkusen their first win in Munich since 1989.
That has since proven to be the last time Bayern lost in the Bundesliga, and Leverkusen will be looking for a repeat, to prevent Bayern from making it half a century of games unbeaten.
"We're not travelling to Munich just to be friendly guests," said goalkeeper Bernd Leno after Wednesday's morale-boosting performance against Paris Saint-Germain in the Champions League.
"We respect them, but we're not scared of Bayern. Why shouldn't we get something from there?"
Leverkusen lost 2-1 in the French capital, but Leno was not alone in theorising that it was his side's "best performance of the second half of the season" so far.
"If you can hold your own against Paris, then you can also survive against Bayern," said coach Sami Hyypia.
"We can take a lot of positives out of this game."
A win for Leverkusen would be more than welcome, especially with Schalke closing the gap on them last weekend.
Without a win in seven matches, Leverkusen are now clinging on to a place in the Champions League next season as the Bundesliga heads into its final 10 matches.
Schalke can steal a march on Leverkusen on Friday night when they travel to Augsburg, who are mounting their own charge for a maiden qualification for Europe next season.
Second-placed Borussia Dortmund host Borussia Monchengladbach on Saturday keen at least to keep their four-point cushion over Leverkusen and Schalke, although Gladbach, without a win yet in 2014, need to pick up points for their own European ambitions.
Elsewhere, Huub Stevens takes charge of his first game as coach of Stuttgart on Saturday with a trip to Werder Bremen while Hamburg, who are below the Swabians only on goal difference, are not in action until Sunday when they host fellow strugglers Nurnberg in a relegation battle.
Bottom-placed Eintracht Braunschweig host Wolfsburg in a Lower Saxony derby while Mainz do not have far to travel to face Hoffenheim on Saturday.
Hertha Berlin host Hannover on Saturday while the final game of the weekend sees Eintracht Frankfurt entertain Freiburg.