"It's about time we beat them here," said Gladbach coach Lucien Favre, whose side has suffered back-to-back defeats to Bayern Munich and Hannover.
Those two results have seen the Foals slip from third at the turn of the year to fifth, with a place in the Champions League next season now in jeopardy.
"We've lost two in a row and certainly not played as well as we can," Favre added. "But we've now got to remain calm.
"Only small things make the difference and we've just been creating too few chances compared to the first half of the season.
"Just let's not forget that we got 33 points in the first half of the season."
Leverkusen got 37 points in the first four months of the season, adding a further three last weekend to open up a seven-point advantage over their hosts, a gap they hope at least to maintain through the weekend.
To do that, they have to become only the third side after Wolfsburg and Bayern to pick up any kind of positive result at the Borussia Park.
"We know how strong they are at home, but we must focus on ourselves," said Leverkusen coach Sami Hyypia, who may give a debut to new signing Andres Guardado on Friday night.
"Andres looks very good on the ball and he's an option," Hyypia said. "But we've got to give him time.
"He's got to digest our way of playing as quickly as possible and understand our orders."
Martin Stranzl and Roel Brouwers are both doubts for Gladbach while Julian Korb is suspended, meaning Alvaro Dominguez will return to the starting XI after being left out last weekend.