The Westphalians have fallen 12 points adrift of Bundesliga leaders Bayern Munich, who are not in action this weekend due to the Club World Cup, and Klopp wants his side to take this opportunity to reduce that gap.
At the same time, he hopes to get back to winning ways at home, where Dortmund have already been beaten twice this season.
"It's about time we celebrated three points in our own stadium," Klopp said. "To get them, we're going to have to throw everything into the mixer."
Above all, Dortmund need to develop a killer touch in front of goal after "creating an incredible amount of chances" in their recent home games, including the 3-0 defeat to Bayern Munich.
Finding the right balance between attacking and defending is something else Klopp needs to concentrate on, particularly given Hertha's "lightning fast counter-attacking style."
"They're uncomfortable opponents," Klopp said at a press conference. "Our task will be to ensure that we're even more uncomfortable than they are."
The return of midfielder Ronny has helped Hertha in becoming so uncomfortable, although he may not feature against Dortmund given his well-documented fitness issues.
"Dortmund's midfield is like a machine," said coach Jos Luhukay. "They run an average of seven to eight miles each and I've got to consider whether I can do that to Ronny.
"It's going to be hard for him to reach his level of performance with the tempo and pace of the game.
"There is going to be a pain barrier for all of the players, and the question is whether they are willing to go through that."
Should Ronny remain on the bench, Per Skjelbred may start while Johannes van der Bergh is still out with a thigh strain, so Nico Schulz will fill in at full-back.