Since winning their first three games of the campaign, setting a flying pace along with Borussia Dortmund and Bayern Munich, they have lost five and drawn one of their last six matches.
That draw came in their penultimate outing against Hoffenheim, after which they were beaten 4-1 at Bayern.
Furthermore, they have lost Julian Baumgartlinger and Niko Bungert to injuries.
"That's really bitter news," said coach Thomas Tuchel, who is nevertheless confident the players he does select on Saturday can reverse their fortunes.
"Nobody will play who doesn't deserve to," he said. "We're really motivated for this game and feel ready for it.
"Regardless of the many players who are out and the run of form we are in, we believe we can beat Braunschweig. We've got two very important games ahead of us."
Braunschweig coach Torsten Lieberknecht has set his team an unusual target with the ultimate goal of remaining in the top flight next season.
"We want to go where nobody else wants to go - we're fighting for the relegation play-off berth," he said.
"That would be the first step towards our goal. If we get through that, then it would be perfect.
"I'm convinced we will reach our goals."
Braunschweig's spirits have been lifted after a 2-0 win at Wolfsburg, although they were brought back down to earth with a 3-2 defeat to Schalke last time out.