Goals from Ivica Olic and Diego just before half-time were enough for the Wolves to celebrate a 2-0 victory which takes them into the top half of the table, just a point behind their opponents.
Wolfsburg defended their lead in the second half and almost added to it too, but that was not necessary to take the spoils.
Hecking chose Jan Polak to take the place of the suspended Luiz Gustavo in his midfield, recalling him for the first time after the opening-day defeat in Hannover.
His cross in the 14th minute almost led to a penalty, but the referee did not see Hajime Hosogai's handball as deliberate and waved play on.
The hosts kept up their hunt for an opener, but despite them enjoying most of the possession, the first big chance of the game went Hertha's way with Anis Ben-Hatira's cross met by the unmarked Adrian Ramos, who headed over the crossbar from six yards out.
Wolfsburg finally made their pressure count three minutes before half-time when Naldo's shot turned into an assist for Olic, who slid in to meet the ball on the edge of the six-yard box and open the scoring.
A foul by John Brooks on Diego just before the interval allowed the Brazilian to double Wolfsburg's advantage from the penalty spot.
Wolfsburg could have had a third in the second half when Koo Ja-cheol took the ball around Thomas Kraft, but he lost the angle for a shot and instead lifted a cross towards Diego who was unable to reach it.