Frankfurt booked their place in the group stages of the Europa League with a 4-1 aggregate victory over Qarabag while Dortmund were able to enjoy a rare week without any competitive action, and both coaches agree that could give them an advantage.
"So far, we had always hoped that we would have an advantage from our opponents playing in Europe and with a midweek game in their legs, but now the situation is the other way round," said Frankfurt coach Armin Veh.
"Our opponents have been able to prepare while we played, but we're still looking forward to this game."
Klopp says their advantage has got to be capitalised on by his team, who are hoping to avoid a repeat of the 3-3 draw in Frankfurt last season.
"We have an aim and that is to get a result which will earn us points, and that's how we've got to play," he said.
"We are going there with an advantage and any advantage we have got must be made to count.
"I don't expect Frankfurt just to defend. They have a home game and I expect it to be intensive.
"They are a side who don't leave you much room and who get at you in tackles, and they are very strong from set-pieces."
Frankfurt hope to have their top goalscorer from last season, Alexander Meier, back from injury, but Dortmund are still without Ilkay Gundogan and Lukasz Piszczek.