They meet a side in Freiburg who have lost their first two games of the season and are therefore already six points adrift, but the gap between the two teams in reality is almost unperceivable, according to Gisdol.
"The competition in the Bundesliga is so tight that it often comes down to minor things and moments," he said.
"They have been going against Freiburg recently, that's all."
Freiburg coach Christian Streich says it is not only luck which has prevented his side from picking up any points so far, though.
Having sold numerous players this summer, he has had to form a new squad which he thinks would need several more months of work to have playing the way he would like.
"Christian Streich is an incredibly nice coach, but he is also a master of the understatement," said Gisdol, who is reading little into Freiburg's current form and the words of his colleague.
"With a bit more luck, they would have got a point against Leverkusen and their home defeat to Mainz could have been avoided"
Streich is remaining humble, however. "It would be nice if we could give Hoffenheim a challenge and give them a good game," he said at a press conference.
"It's going to be a big challenge for us, but we can do it if we are wide awake."
Freiburg could be without striker Mike Hanke, who injured his knee against Mainz last weekend.
"He may miss out," admitted Streich. "Losing him would be a shame, but we would have to accept it and see if we can find other solutions."
Gisdol has the same players at his disposal as he did for the first two games of the season with just Sebastian Rudy and Jens Grahl out of action.