Both suffered heavy defeats in the Bundesliga last weekend, while Schalke also experienced the disappointment of a 1-1 draw at home to PAOK FC in midweek - a result which compromises their hopes of reaching the group stage of the Champions League.
Hannover conceded three a week ago and changes are therefore going to be made in defence.
Karim Haggui found himself in the back four alongside new signing Marcelo in training this week with Hiroki Sakai losing his place to Salif Sane.
"It's obvious that we have to change something," said coach Mirko Slomka to the Bild newspaper. "I still haven't decided what, though."
Changes were also made in midfield with Lars Stindl starting on the right and Leon Andreasen playing in a defensive midfield position.
"I just wanted to see how it worked," added Slomka, who is scratching his head prior to the meeting with his former club.
Slomka led the Royal Blues to the quarter-finals of the Champions League in 2008 before being fired after they lost to Barcelona.
Given their midweek performance against Greek side PAOK, the likes of Barcelona are not going to be paying the Arena AufSchalke a visit this season, although before contemplating the second leg in Salonika next Tuesday, the Royal Blues need to pick up some self-confidence in Hanover.
They will almost certainly have to do so without Wednesday's goalscorer Jefferson Farfan.
The 28-year-old has a sore ankle after leaving the field late on against PAOK, but he is not Jens Keller's only doubt.
Sead Kolasinac missed out on Tuesday and is ruled out also tomorrow while Klaas-Jan Huntelaar is out of action for a month.