Mainz could move clear at the top of the Bundesliga with a win over the Wolves, but Tuchel claims his side's performances from their 3-2 win against Stuttgart and 2-1 triumph over Freiburg would not be good enough for further three points.
"We've got to do everything even better," he said at a press conference. "Given all of the individual quality our opponents have, we are not going to be able to avoid them getting through at some stage over the 90 minutes or that we may lose a tackle here or there.
"We are going to have to support each other and help each other out."
Speaking about support, Tuchel expressed his shock and dismay that the Coface Arena is not yet a sell-out.
Several thousand tickets will be on sale at the stadium and Tuchel hopes they will be snapped up.
"How can this game not be sold out yet?" he asked. "We need everybody
"We're up against very strong opponents, the weather's going to be beautiful. We certainly expect a few thousand more to come."
Wolfsburg will not have too many fans following them south while Bas Dost and Maximilian Arnold will also miss the trip due to injury and suspension respectively.
Timm Klose is back, on the other hand, and he is vying with Robin Knoche for a place in the heart of the defence alongside Naldo.
"Robin played a very good game (against Schalke) and it's a high-level battle between him and Timm," said Wolves' coach Dieter Hecking. "The important thing is that we have a squad which allows us to react when players are out."