Local rivals Borussia Monchengladbach arrive at the BayArena off the back of a 3-0 win over Hannover a week ago and Hyypia says the fans will have an important role to play in defeating them.
"Last season, we played in front of a full house and it was a fantastic atmosphere," he said.
"That is going to be important for my team tomorrow [Saturday], to have the fans behind them. It could lift us."
Gladbach lost their opening game of the season 3-1 at Bayern Munich, but showed signs of their quality even in that game, which is why Hyypia is so wary.
"They always try to hit you with a fast counter-attacking style," he said at the pre-match press conference. "They have some very good passers of the ball among their ranks for that.
"It's going to be important for us to be quick and precise to find gaps where we can cause Borussia problems."
His counterpart Lucien Favre said almost exactly the same thing about how his side is going to have to play.
"We've got to play quickly at the right time," he said. "Either down the wings or down the middle.
"We're certainly not going to find as many gaps as we did against Hannover.
"There is no doubt about it, Bayer are a very good team who are not playing in the Champions League by fluke."
Favre has a fully-fit squad of players to chose from while Hyypia has just one doubt, over Sidney Sam.
"He got a kick against Stuttgart and it has got worse in training," said the Finn. "Therefore, he could not train and we'll have to see if he will be ready."