Also on Saturday, Bayer Leverkusen, who finished third last term, will host Freiburg, who came fifth.
Sandwiched in between them were Schalke, who are optimistic that they can have a greater say in where the title ultimately ends up this season, although they will have to wait until Sunday before making their season bow against Hamburg.
"I believe we are better equipped this year compared to the last one," Schalke's director of sport Horst Heldt told Der Westen newspaper.
"I also get the feeling that the team has learned from what didn't go so well last season, but of course this is all only a feeling right now. I just hope my feeling does not betray me."
Elsewhere, northern Germany rivals Hannover and Wolfsburg meet at the Niedersachsenstadion while Hoffenheim host Nuremberg and Eintracht Frankfurt travel to the capital to face Hertha Berlin on Saturday.
Saturday evening's match sees Eintracht Braunschweig return to the Bundesliga for the first time in 29 years against Werder Bremen while Europa League participants Stuttgart are in action on Sunday at Mainz.
Earlier on Friday, Pep Guardiola made a winning start to life as Bayern Munich coach as the defending Bundesliga champions opened with a 3-1 win over Borussia Monchengladbach.
Friday's Bundesliga Result
Saturday's Bundesliga Fixtures
Sunday's Bundesliga Fixtures
Mainz vs Stuttgart
Schalke vs Hamburg