They begin their sixth straight campaign in Germany's top flight with a home game against Nuremberg on Saturday, aware of how close they were to playing in the 2. Bundesliga this season and thus keen to make the most of an unexpected reprieve.
Going into the final minutes of last season, Hoffenheim were following Greuther Furth down the Bundesliga trapdoor, but a dramatic twist with two penalties in a handful of minutes to beat Borussia Dortmund away kept Markus Gisdol's side up.
They then defeated Kaiserslautern in a two-legged play-off to preserve their Bundesliga status.
"We all know where we are coming from," said Gisdol. "We know that last season wasn't easy and it is now up to us to win back our fans bit by bit.
"You can clearly sense the anticipation of this game, not just among the players.
"We've trained well, prepared well and now the time has come for things to get under way."
Part of those preparations included a 9-0 win in the first round of the DFB-Pokal last weekend, a result which will give them confidence, unlike Nuremberg's penalty shoot-out elimination to Sandhausen.
"Of course the pain from the Sandhausen defeat is still strong," said their coach Michael Wiesinger.
"We wanted to start the season with a highlight and we missed this opportunity, but we must move on.
"We now want to start with a positive result. What matters is the here and now.
"I have sensed quite clearly that the lads are motivated and we want to gift our fans a successful opening Bundesliga fixture."
Wiesinger takes a fully-fit team with him to Sinsheim while the hosts also have their entire squad in training, although there remain question marks over the condition of David Abraham, Sejad Salihovic, Sven Schipplock and Anthony Modeste, who only returned to action on Thursday and are carrying minor knocks.