Shingo Akamine scored the opener on the stroke of half-time, with Kunimitsu Sekiguchi (58), Yoshiaki Ota (76) and Jiro Kamata (87) adding second-half strikes.
Vegalta remain the only unbeaten team in the league and have now put breathing space between themselves and Nagoya Grampus Eight, who were held to a 1-1 draw at Sanfrecce Hiroshima.
A 63rd-minute goal from Hayuma Tanaka looked to have given Nagoya the points, but Ryota Moriwaki levelled in the dying seconds.
Hiroki Yamada's 36th-minute effort earned Jubilo Iwata a 1-0 victory at home to Yokohama F. Marinos, a result which lifts them into third place.
Consadole Sapporo continue to prop up the standings after a 3-2 loss to Kawasaki Frontale.
The home side were two goals ahead thanks to Shunsuke Maeda (nine) and Jumpei Takaki (32), but Kawasaki hit back in the second half through Kengo Nakamura (57) and Renato (67pen) before Koji Yamase's strike two minutes from time settled the contest.
Goals from Sergio Dutra, Shinzo Koroki and Yasushi Endoh earned Kashima Antlers a 3-2 win at home to Cerezo Osaka, who had led through Kim Bo-Kyung's first-half double.
Tozin's goal 10 minutes from time sealed a 1-0 victory for Sagan Tosu over Albirex Niigata.
Vissel Kobe beat Kashiwa Reysol 3-1 with efforts from Takuya Nozawa, Keijiro Ogawa and Yuzo Tashiro. Kashiwa's reply came from Masakatsu Sawa.
Cho Young Cheol and Rafael Marques were on the scoresheet as Omiya Ardija overcame Urawa Red Diamonds 2-0.