Goals from Bowen Huang (19) and Luiz Muriqui (40) gave Guangzhou the edge before Bruno Meneghel pulled one back for the visitors after 64 minutes.
But they failed to add to their tally and Dario Conca's strike in stoppage time wrapped up a 23rd win in 28 matches for the hosts.
Defeat leaves Qingdao one point from safety with two matches remaining.
Wuhan Zall have already lost their battle to beat the drop and suffered another loss on Sunday, with Ivan Cuadrado's 45th-minute goal earning Shanghai SIPG a 1-0 win.
Eninho, Jan Rezek and Cao Tianbao were the scorers as Changchun Yatai beat Tianjin Taida 3-1. Xinxin Wang grabbed the visitors' consolation.