Manzano's comments come ahead of Beijing's AFC Champions League match against the Brisbane Roar on Tuesday.
Beijing will need to win or draw the match to secure their place in the knockout stage of the tournament as they currently sit atop the Group G standings with 10 points.
Even though Beijing drew 2-2 with Guizhou Renhe in the Chinese Super League on Friday, Manzano is confident his side can get the job done against Brisbane.
"From the data I can see now, Zhao Heijing should play, but I can't guarantee anything until I see his training," he told the official AFC website. "On top of that, Xu Yunglong is recovered, and Li Lei is also ok with his ankle now. If they are all well in the training, that is a good news for us.
"We have to win the game to nail down the qualification. We are aware that our opponent has to win to avoid elimination. But we are confident at home; we won't give them any opportunities.
"The game against Guizhou last weekend was an accident. I believe my players can cope with tomorrow's match."
Meanwhile, Brisbane find themselves in a huge predicament heading into the match as they have to win to stay in contention for the knockout stage of the tournament.
If they lose, they will be eliminated. However, should the match end as a draw, Brisbane will need Urawa Red Diamonds to beat Suwon Samsung FC.
"Our opponents have done very well in the AFC Champions League so far and I know that Beijing have a lot of good players with different combinations in the frontline, so our main mission will be to cancel out their forwards," Brisbane coach Frans Thijssen said. "It was a long trip for us to travel here and we’ve had only three days to prepare, so I will be looking to rotate some players.
"We are looking forward to this game and we hope it will be an entertaining one."