Should the J.League side beat Suwon Bluewings, they will secure qualification for the Round of 16 with two games remaining.
Nelsinho Baptista's side extended their 100% record this season with a thrilling 6-2 win over Suwon last Wednesday thanks to two goals each from Junya Tanaka, Ryoichi Kurisawa and Masato Kudo.
And should a fourth consecutive win in Group H arrive at Hitachi Kashiwa Stadium next week, Kashiwa will secure a place in the Round of 16 for a second consecutive season having lost to eventual champions Ulsan Hyundai on their debut appearance at the same stage last season.
"There were several moments of challenge from home side, but we were able to endure them and we scored when we needed to," said Nelsinho after the win at Suwon World Cup Stadium.
"We are still on the top of the table and this result is a big step forward to the knockout stage of this season's AFC Champions League."
Nelsinho will, though, be forced into at least one change for the return fixture with defender Naoya Kondo ruled out through suspension.
The defeat left 2011 semi-finalists Suwon, who incredibly converted just one of four second half penalties having trailed by just a single goal at the break, without a win in Group H after beginning the campaign with back-to-back draw, although Seo Jung-won's side are just two points adrift of second place Central Coast Mariners.
The Mariners, who enjoyed a weekend break from domestic action ahead of their A-League final series semi-final next Sunday, kept themselves firmly in the qualification picture as Trent Sainsbury's first goal for Central Coast secured a 2-1 win over China's Guizhou Renhe last Wednesday.
The win represented just a second victory in three AFC Champions League campaigns for the Mariners, who can end Guizhou's maiden continental campaign with a second consecutive win at Guiyang Olympic Sports Centre Stadium on Tuesday.
In Group F, Chinese Super League champions Guangzhou Evergrande can also secure a second consecutive place in the Round of 16 with victory over Thai champions Muangthong United should Jeonbuk Hyundai Motors beat fellow former champion Urawa Red Diamonds.
After Guangzhou cemented their position at the top of Group F with a comprehensive 4-0 win over Muangthong at Tianhe Stadium on Wednesday and Jeonbuk came from behind to beat Urawa 3-1 in Japan, the same series of results on Matchday Four would also end the maiden continental campaign of the Thai champions.
Guangzhou currently top of the table ahead of 2006 champions Jeonbuk, who are also unbeaten after three games, with 2007 winners Urawa a further two points adrift.
Striker Teerasil Dangda, who was the top scorer in the Thai Premier League last season, will miss the game for Muangthong due to suspension although coach Slavisa Jokanovic does have Piyaphon Buntao eligible to return.
In the West, Iran's Esteghlal will seek a repeat of Wednesday's stunning 2-1 victory over Al Hilal to potentially secure qualification from Group D, while Qatar's Al Rayyan entertain UAE Pro League leaders Al Ain.
Pejman Montazeri and Arash Borhani scored in the final 10 minutes as Esteghlal returned to the top of Group D by stunning Al Hilal at Azadi Stadium.
And Amir Gholenoei's side can seal a place in the Round of 16 for a second consecutive season with a third win in four games on Tuesday as long as Al Rayyan fail to beat Al Ain in Doha.
Al Rayyan, who lost 2-1 to Al Ain on Wednesday, will be eliminated if they lose again to Al Ain and Esteghlal avoid defeat against Al Hilal.
Coach Diego Aquirre does welcome back Uruguayan midfielder Alvaro Fernandez from suspension as Al Rayyan seek a first win of the campaign, although Guinean-born midfielder Daniel Goumou is ruled out after picking up a second yellow card of the campaign against Al Ain.
Finally in Group B, Uzbekistan champions Pakhtakor entertain Qatari counterparts Lekhwiya in Tashkent, while UAE Pro League side Al Shabab Al Arabi travel to Dammam to face Al Ettifaq.
Lekhwiya ended Pakhtakor' s perfect start with a 3-1 win in Doha on Wednesday thanks to two late goals from Qatar international Sebastian Soria, while Nasser Masood scored the only goal of the game with nine minutes remaining as play-off winners Al Shabab Al Arabi revived their campaign with a 1-0 win over winless Al Ettifaq in Dubai.
The win lifted Lekhwiya a point clear of Pakhtakor at the top of the table, with Al Shabab Al Arabi just three points behind second place Pakhtakor.
Tuesday's AFC Champions League Fixtures
Pakhtakor vs Lekhwiya
Al Ettifaq vs Al Shabab Al Arabi
Al Rayyan vs Al Ain
Esteghlal vs Al Hilal
Jeonbuk Hyundai Motors vs Urawa Red Diamonds
Muangthong United vs Guangzhou Evergrande
Kashiwa Reysol vs Suwon Bluewings
Guizhou Renhe vs Central Coast Mariners