The J-League side scored five times in the second half as they ran away with the match.
Junya Tanaka, Masato Kudo and Ryoichi Kurisawa all netted twice, while the hosts' goals came from Choi Jae-soo and a Stevica Ristic penalty.
Central Coast Mariners moved up to second in the pool with a 2-1 win over Guizhou Renhe, although they remain five points behind Kashiwa.
The Australians led through Pedj Bojic's goal in the 50th minute, but were pegged back when goalkeeper Matthew Ryan put through his own net.
But Trent Sainsbury grabbed the winner 10 minutes from time to earn the hosts their first win in the group.
Guangzhou Evergrande strengthened their position at the top of Group F with a 4-0 thumping of Muangthong United, all four goals coming after the break.
Dario Conca made the breakthrough in the 51st minute and Luiz Muriqui added a second seven minutes later.
There was no way back for the Thai visitors as an effort from Lin Gao and another Conca strike sealed victory for the Chinese outfit.
Jeonbuk Motors came from behind to win 3-1 at Urawa Red Diamonds.
The hosts went in front after six minutes through Genki Haraguchi and led at half-time.
But Lee Seung-gi (51), Lee Dong-gook (64) and Eninho (70) netted as the visitors completed a second-half comeback.
In Group B, Lekhwiya knocked Pakhtakor off top spot as a late brace from Sebastian Soria earned a 3-1 home win over the Uzbek League side.
Issiar Dia put the hosts ahead after 21 minutes, but Gulom Urunov levelled five minutes before the break.
Soria struck in the 84th and 90th minutes to win it for Lekhwiya.
Elsewhere, Al Shabab got their first win as Naser Masood's 81st-minute goal secured a 1-0 win at home to Al Ittifaq.
Esteghlal stayed top of Group D with a 2-1 win at Al Hilal thanks to two goals in the last 10 minutes.
Al Hilal went head through Salem Al-Dosari in the 68th minute, but Pejhman Montazeri equalised in the 80th minute and Arash Borhani got the winner five minutes later.
Al Ain are second after a 2-1 home win over Al Rayyan, but they too had to come from behind.
Nilmar gave Al Rayyan the advantage in the 32nd minute, but Jires Ekoko levelled things up just two minutes later.
Alex Brosque won it in the 69th minute.
Wednesday's AFC Champions League Results
Lekhwiya 3-1 Pakhtakor
Al Shabab 1-0 Al Ettifaq
Al Ain 2-1 Al Rayyan
Al Hilal 1-2 Esteghlal
Guangzhou Evergrande 4-0 Muangthong United
Urawa Red Diamond 1-3 Jeonbuk Motors
Suwon Bluewings 2-6 Kashiwa Reysol
Central Coast Mariners 2-1 Guizhou Renhe