Henrique and Erik Paartalu scored in Brisbane on Saturday as the Roar won the first leg of the Hyundai A-League major semi-final, although the Premier's Plate-winning Mariners can still earn direct entry to the Grand Final with Sunday's return fixture being played on home soil.
And with Seongnam also making the trip to the Central Coast, the Mariners face crucial back-to-back home games after beginning their AFC Champions League campaign in a tightly contested Group G with draws against China's Tianjin Teda and Japan's Nagoya Grampus.
Two weeks ago, the Mariners were denied a first win in the competition as Nagoya survived to claim a 1-1 draw following a dominant second half display from the home side.
"As players, these are the games that you want to be playing in. The AFC Champions League is great, we're loving it, we're definitely embracing it," said Mariners captain Alex Wilkinson following the defeat by Brisbane.
"You're very happy at the end of the year when you qualify for the AFC Champions League, so I think it's a reward that you should enjoy playing in.
"So far we've had two great results and the boys will be up for it again on Tuesday - we need another good result, our group's very very close.
"And I think that after a disappointing result against Brisbane the best thing to do is to get out on the pitch and forget about this and you've got a whole new game to think about."
The visit of Seongnam represents the halfway point of the Group Stage and, as well as being the Mariners' penultimate home game, coach Graham Arnold will hope to see the same level of commitment rewarded with a first three points in the continental competition.
Seongnam, who drew 1-1 at home to Tianjin two weeks ago to leave all four teams level on two points, head to Australia following a 1-0 home defeat by Busan I'Park in the K-League on Friday to leave Shin Tae-yong's side with just one win this season.
Tianjin, meanwhile, head into their meeting with Nagoya at Tianjin Teda Football Stadium after losing 3-1 to Beijing Guoan in the Chinese Super League on Saturday, while the visitors continued their solid start to the new J.League season with a 1-1 draw at Omiya Ardija at the weekend.
In Group E, Adelaide United take their 100% record to Korea to face a Pohang Steelers side looking to bounce back from being outplayed by Bunyodkor at home on Matchday Two.
Adelaide followed up their impressive opening day win in Tashkent over Bunyodkor with a 2-0 win over Gamba Osaka two weeks ago thanks to two first half goals from defender Daniel Mullen, and will look to extend their unbeaten streak in all competitions to six games at the Steelyard.
"It's a massive opportunity. It's a fantastic competition and we've put our best foot forward in the first two games and if we can keep on that uptrend then there's no reason why we can't take this opportunity with both hands," said Reds striker Bruce Djite, who scored as Adelaide beat Pohang 2-0 in Korea during the Group Stage in 2008.
"I don't think there is any danger of any complacency creeping in because we're not even close to qualifying yet and it's hard to go anywhere and get points. The six points we've got have definitely given us a head start and we're in poll position, but it's a matter of staying concentrated, keeping our feet on the ground and getting the other four or five points we need to qualify."
While the Reds rounded off a disappointing A-League season with a third consecutive draw over a week ago, Pohang beat Chunnam Dragons in the K-League on Friday following the 2-0 home defeat by Bunyodkor in the AFC Champions League two weeks ago.
Gamba Osaka, meanwhile, will hope the impact of new coach Masanobu Matsunami will extend into the AFC Champions League against Uzbekistan champions Bunyodkor following Saturday's 1-1 draw with Albirex Niigata.
Matsunami, who made 280 appearances for Gamba in a 13-year career before retiring in 2005, was appointed at the end of March 2012 after Gamba suffered five straight defeats in all the competitions under Brazilian coach Jose Carlos Serrao.
In the West, in-form Esteghlal entertain Group A leaders Al Jazira, while newly crowned Qatar champions Lekhwiya travel to Iran to face Pro League leaders Sepahan.
Esteghlal are unbeaten in the Iran Pro League since the start of February and beat Malavan 1-0 on Wednesday, while Parviz Mazloomi's Hazfi Cup winners have made an unbeaten start to the AFC Champions League this season.
The play-off winners began the continental campaign with a 1-0 win over Al Rayyan in Qatar, but Esteghlal were frustratingly held to a goalless draw by Nasaf two weeks ago as Al Jazira's 3-2 home win over the Qatari side lifted the UAE Pro League champions two points clear with a100% record.
Al Jazira have made a perfect start in Group A wins over Nasaf and Al Rayyan, but head to Iran following a 3-2 defeat by Emirates in the UAE Pro League on Thursday.
AFC Cup winners Nasaf, who have made a perfect start to the new domestic season in Uzbekistan, travel to Qatar to face Al Rayyan after picking up their first point in the AFC Champions League against Esteghlal.
Finally in Group C, Lekhwiya face a tough trip to Iran buoyed by ensuring a return to the AFC Champions League next season by retaining the Qatar Stars League title at the end of March.
Lekhwiya made a strong start to their maiden continental campaign with a 1-0 win over Al Ahli, but lost 2-1 to Al Nasr two weeks ago.
Sepahan, who drew 1-1 at home to Al Ahli on Matchday two, are also on course to retain their domestic title with Zlatko Kranjcar's side three points clear at the top of the table with six games remaining.
Also in Group C, Al Nasr entertain Al Ahli in Dubai looking to build on the win over Lekhwiya, which was secured as Amara Diane netted his second of the match in stoppage time.
Diane ensured Al Nasr head into the contest full of confidence after the Ivory Coast international also scored twice to secure a 3-2 win over Al Sharjah in the UAE Pro League on Thursday.
Tuesday's AFC Champions League Fixtures
Esteghlal vs Al Jazira
Al Rayyan vs Nasaf Qarshi
Al Nasr vs Al Ahli
Sepahan vs Lekhwiya
Gamba Osaka vs Bunyodkor
Pohang Steelers vs Adelaide United
Tianjin Teda vs Nagoya Grampus
Central Coast Mariners vs Seongnam Ilhwa Chunma