A victory for Russia against Slovakia in Group B on Wednesday will all but secure their progression to the last 16 of Euro 2016.
Leonid Slutsky's side held England to a 1-1 draw in their opening game on Saturday, in a fixture that was overshadowed by trouble that flared in Marseille and at Stade Velodrome.
Although the two teams meet for the first time ever at a major tournament, the Russians have an upper hand, having won four of their last five friendly outings against the Falcons.
Jan Kozak's men, on the other hand, are searching for their first European Championship victory after conceding in the dying moments to lose 2-1 against Wales in their Group B opener in Bordeaux on Saturday.
Kozak admits that changes to his starting line-up are a certainty ahead of the clash at Stade Pierre-Mauroy.
"There will definitely be changes, but I cannot say which ones yet. We'll see what shape the players are in after their recovery session," he said.
"We've watched both teams. We had people at the other game (England against Russia). We know what we have to do, that we have to prepare well and attempt to get a better result than we did against Wales."
In team news, Dmitri Torbinski and Denis Glushakov are both in the treatment room and they are unlikely to be risked by Slutsky.
Meanwhile, Kozak has no fresh injury worries ahead of the game and he is likely to stick to a 4-2-3-1 formation.