By FOX SPORTS staff
Both sides have played each other enough number of times this season to know exactly what to expect from the other's ranks, which could make this one a tight and nervy encounter.
With the Premier League title in the bag, Manchester United will go out on the pitch looking to salvage the pride lost when they were knocked out of the FA Cup by Chelsea, so expect Sir Alex Ferguson to unleash his big guns in a bid to prove that the defeat was a fluke.
The stakes are much higher for Rafa Benitez's side, who watched London rivals Arsenal and Tottenham pick up victories on Saturday. Although the Blues might finish the season with a new piece of European silverware, they are aware that owner Roman Abramovich will not be in a forgiving mood if they fail to make the cut for the Champions League.
Predicted starting XIs
Man United: De Gea, Rafael, Vidic, Ferdinand, Evra, Jones, Carrick, Valencia, Nani, Rooney, van Persie
Chelsea: Cech, Azpilicueta, Cole, Ivanovic, Luiz, Mikel, Ramires, Oscar, Hazard, Mata, Ba
Robin van Persie vs David Luiz
Having put his goal drought behind to win April's Premier League Player of the Month, van Persie will be keen to notch up more with just three games left in this campaign.
Coming up against one of the league's most proficient strike pairings, the Chelsea central defence needs to be at the top of their game. Benitez sung Luiz's praises earlier on in the week, so the Brazilian will be keen to bolster his reputation further by keeping van Persie quiet and perhaps weigh in with another one of his trademark long-range goals.
Phil Jones vs Juan Mata
The Spaniard is widely considered as Chelsea's most lethal weapon, and with his arsenal of playmaking, dribbling and shooting skills, Mata will fancy himself to prevent compatriot David De Gea from finishing the game with a clean sheet.
Ferguson will very likely unleash the man he expects to be United's "best ever player" to keep tabs on Mata. The former Blackburn player's versatility has impressed many this season and Jones will be tasked to shield the defence from Mata's probing in this one.
Nemanja Vidic vs Demba Ba
The Red Devils need no reminder of what Ba is capable of, after seeing their hopes of winning a domestic double demolished at the end of the former Newcastle man's boot. Although Ba has not been as prolific as Chelsea fans would like, his tireless work rate should keep the United defence busy throughout the game.
Ferguson will be pleased to have Vidic back, as the Serbian's awareness in and around the box is unlike any other. Vidic must keep a close eye on Ba's movement in the danger area in order to prevent a repeat of their cup heartache.
Rafael vs Eden Hazard
United full-back Rafael has benefitted tremendously from a regular spell in the starting XI, becoming one of the team's key performers in their title-winning campaign. The Brazilian will be on his toes in the game as he tries to keep Hazard quiet and he could spring an attacking surprise of his own if the former Lille man does not track back to help Ashley Cole.
Hazard has yet to achieve a consistent run of form in the second-half of the season, but Benitez will be hoping for the 22-year old to help Mata out in the task of unlocking the Red Devils backline. The Belgian can prove very hard to stop on his day, as many Premier League sides, including United, can attest.
Wayne Rooney vs John Obi Mikel
Speculation regarding Rooney's future continues to mount in the English newspapers, with United linked to several top strikers this summer. The former Everton man has been short on goals, but his assist for van Persie during the win against Aston Villa proves he could still be useful to the team's attack and he may look to emphasize his point further to Ferguson against Chelsea.
With Rooney expected to come from deep in his attacks against the Blues defence, Mikel must turn in an attentive and conscientious performance while shielding his defenders or risk being exposed by the England international.