Here is a look at some memorable past meetings between the two old rivals, just a fortnight after they last met in the FA Cup.
LIVERPOOL 2-1 MANCHESTER UNITED (FA Cup fourth round, January 28, 2012)
Dirk Kuyt scored an 88th-minute winner to knock Manchester United out of the cup and gained revenge for their exit at the hands of their arch-rivals 12 months previously. Park Ji-sung's equaliser just before half-time looked like sending the tie to a replay after Daniel Agger's header put the hosts ahead. However, Kuyt, with his second goal of the season, fired past David de Gea late on.
LIVERPOOL 1-1 MANCHESTER UNITED (Premier League, October 15, 2011)
Steven Gerrard and Javier Hernandez scored as the teams drew at Anfield. However, the match became notorious for the dispute between Luis Suarez and Patrice Evra which later saw the Liverpool striker banned for eight matches for racially abusing the Manchester United defender.
MANCHESTER UNITED 3-2 LIVERPOOL (Premier League, September 19, 2010)
Dimitar Berbatov scored his first hat-trick for United to settle a pulsating clash after they had squandered a two-goal lead. Berbatov struck either side of the interval, the second a brilliant overhead kick. But United's defence capitulated, Steven Gerrard scoring with a penalty and a free-kick before Berbatov came to the hosts' rescue six minutes from time.
MANCHESTER UNITED 1-4 LIVERPOOL (Premier League, March 14, 2009)
Liverpool enjoyed a deserved crushing of 10-man Manchester United. Cristiano Ronaldo put the Red Devils ahead from the spot but Fernando Torres and Steven Gerrard turned the match on its head before the break. Fabio Aurelio curled home a superb free-kick after Nemanja Vidic capped a dismal display with his second red card of the season against the Merseysiders, before Andrea Dossena lobbed home another in stoppage time.
LIVERPOOL 2-3 MANCHESTER UNITED (Premiership, September 11, 1999)
Jamie Carragher endured one of his darkest days in a Liverpool shirt as he scored two own goals in the home defeat by the Red Devils including an unstoppable header past Sander Westerveld. Andy Cole also scored for United and, although Sami Hyppia and Patrik Berger were on target for the Reds, it was the visitors' day, despite them having to play for 20 minutes with 10 men following Cole's red card.
LIVERPOOL 3-3 MANCHESTER UNITED (Premiership, January 4, 1994)
Manchester United would finish 32 points ahead of their rivals at the top of the table with this pulsating classic a highlight for the home side. United romped into a three-goal lead within 24 minutes through Denis Irwin, Steve Bruce and Ryan Giggs. However, Nigel Clough pulled one back from long range before getting a second and with a little over 10 minutes left, Neil Ruddock levelled as Anfield erupted.