The last time Liverpool and Manchester United faced off was last season's Premier League encounter at Anfield where the Reds won 3-1.
Things have started well for both sides this season. United are yet to lose in the league while Liverpool, despite having lost twice, have done enough to show they can take one of the coveted top four places.
Former Liverpool and United stars Steve McMahon and Paul Parker, pundits now for ESPN Star Sports - weigh in on Saturday's big upcoming game.
Q: What are your predictions for this Saturday's game?
Paul Parker: Manchester United have started well, but haven't been too good in their recent games. It will be a close game, but United should still win.
Steve McMahon: I do fancy Liverpool. Especially at home, I think they will do very well.
I'm still not very convinced with United because of the changes in the back-four. They keep shuffling and changing. Further, their defending is not very convincing.
Q: Liverpool have always had a good record against Manchester United at Anfield. Do you think Liverpool's defence against Man United this weekend will be good enough?
Paul Parker: It all depends on whether Rooney will play and what he does up front. Sir Alex Ferguson didn't allow Danny Welbeck to play for the England Under-21s, which suggests to me that he will start with the youngster.
Javier Hernandez was well off the pace against Norwich. He didn't play well at all and ended up being taken off. I think the thing Liverpool lack is pace at the back. That's why I think that Welbeck is probably the one who Fergie will go with over Hernandez. Welbeck can get around the park and gets a bit more play. While he might not be as strong a goal scorer, he's a better link player than Hernandez.
There are definitely going to be goals in the game, but it all depends on who Ferguson puts at the back. Nemanja Vidic is close, but I think this game might be a bit too early for him.
So what does he do in the middle in defence? Does he go with Johnny Evans, Rio Ferdinand or Phil Jones? He has to be sure.
Out wide, he has tried Valencia who is okay in one-off situations, but not as a regular full-back.
Steve McMahon: Yes, I think Liverpool will be really up for it. I do think Steven Gerrard will play a big part against Manchester United. He always does. I just feel that it is the right time for Liverpool to take on Manchester United.
Q: With the top of the league currently being dominated by the two Manchester teams, do you think Manchester United still consider Liverpool their greatest rival? Or have Liverpool already been superseded by Manchester City?
Paul Parker: Regardless of what league position Liverpool occupy, they are still Manchester United's greatest rivals because it isn't all about football; it's about the two cities as well.
Football plays a part but the cities themselves are fierce rivals. That's why the rivalry is so strong. It has been taken from the canals onto the football pitch, and it has been going on for years. Liverpool could be finishing second from bottom in the Premier League and still play Manchester United and it will still be a big game.
But Manchester United will win, because it'll be the first time for players such as Andy Carroll and Charlie Adam. Henderson hasn't been involved and I don't know if he will play in it.
Steve McMahon: I think Liverpool- United clashes have always been the biggest games of the season.
Q: What are the advantages that both teams have against the other?
Paul Parker: The advantage for United is having players who are on form upfront: Welbeck and Rooney. For Liverpool, their biggest advantage is playing at home.
Their other big advantage is Luis Suarez. Without him upfront, they are not much of a threat. Suarez is the focal point for Liverpool without a shadow of a doubt.
Steve McMahon: The obvious advantage for Liverpool is being on home ground. It is crucial at the start of the game- the crowds and the atmosphere. Being at Anfield is definitely a big bonus for Liverpool. Manchester United have the momentum and confidence of not being beaten. They should go into the game feeling happy about themselves.
Q: What do you think is the mindset of the clubs right now? Is it more about the league or the traditional rivalry?
Paul Parker: For Liverpool, their focus is to put themselves back in the frame of competing for the EPL, more importantly getting three points closer on the grid to Manchester United and also three points closer to a Champions League spot.
For Manchester United, the main thing is to go and win a game of football against their greatest rivals and to make sure that they don't allow City to pass them in the league. A draw would be good, unbeaten still, but I'm sure Sir Alex would want to win the game.
Steve McMahon: It is about the match result. For Liverpool it is about beating United. They can't think any further than just winning this game. It is about winning games one at a time, and if Liverpool win, they will gain the momentum and look good. This one is really important for Liverpool.
Q: As former players yourself, what were your feelings before your game against Manchester United/ Liverpool?
Paul Parker: Nervous. You do not want to lose because you know it has such a big influence on the rest of your week. Living in Manchester makes a difference when you're in a football club that gets beaten by Liverpool. It used to make me nervous being there after being beaten by Liverpool. Your next game is even more important because you have a grouchy manager.
Steve McMahon: You get very hyped up and very excited, but you've got to watch your temperament. Honestly, Liverpool against Manchester United is a little bit more important than other games for me, given the pressure. It is about the fear of failing; it's what players have all got in common. It's the fear of losing.
Catch the Liverpool vs Manchester United viewing event at ESPN Grandstand this Saturday October 15, and be part of the fun and festivities at Red Carpet Avenue, Encorp Strand (Kota Damansara, Petaling Jaya), starting at 6.00pm before the 7.45pm kick-off.
Catch the Liverpool vs Manchester United viewing event at ESPN Grandstand next Saturday October 15, and be part of the fun and festivities at Epicentrum Walk, Oval Atrium Kawasan Rasuna Epicentrum. Jl. HR Rasuna Said, Jakarta, at 5.00pm before the 6.45pm kick-off.