Cleveland carried a 4-2 lead into the bottom of the 8th, but ended up losing both the lead and the series to San Francisco.
Cincinnati pitching has allowed 46 runs during the losing streak.
Mike Zunino and Nelson Cruz also homered for the Mariners as they tied a season high with four homers to win their fifth straight game.
Washington has gone yard 10 times in the series.
Red Sox manager John Farrell put the game under protest after an odd sequence in the 11th.
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